Isotretinoin, a potent derivative of Vitamin A, is renowned for its effectiveness in treating severe acne, but it is also known for initiating an initial flare-up known as “the purge.” This period can be challenging for many patients, as it often involves a temporary worsening of acne symptoms. Understanding what happens in your body during this phase can help manage expectations and mitigate discomfort. This article explores the mechanisms behind the purge, how to manage it, and additional considerations for navigating this temporary yet difficult phase in the journey to clearer skin.