Tramadol

Tapentadol and Tramadol are both prescription medications used to treat moderate to severe pain. While they share similar applications, their mechanisms, effectiveness, and side effects differ. Tapentadol works as a mu-opioid receptor agonist and norepinephrine reuptake inhibitor, making it effective for nociceptive and neuropathic pain, whereas Tramadol acts as a weaker mu-opioid receptor agonist and also inhibits norepinephrine and serotonin reuptake. Tramadol’s abuse in India led to its ban, resulting in a dangerous black market for counterfeit versions often laced with fentanyl. Tapentadol, available legally, is recommended for safer pain management.