Accutane, the well-known brand-name drug used to treat severe acne, has been a cornerstone in dermatology for decades. Its generic equivalent, isotretinoin, offers the same potent effectiveness at a fraction of the cost. This article delves into the comparison between Accutane and generic isotretinoin, focusing on their active ingredients, additional components, and the implications for those suffering from severe acne. By examining factors such as cost, patient experience, and economic considerations, readers can make informed decisions about their acne treatment options.